Non sedating antihistamine Livecamchatfree
The non-sedating antihistamines include cetirizine, desloratadine, fexofenadine, levocetirizine and loratadine.In overdose they cause mild CNS depression, in therapeutic and supra therapeutic doses they have been associated with QT prolongation.Antihistamines like Zyrtec and Claritin are designed to calm the histamine reaction your body has when it’s exposed to an allergen.
It is concluded that there is no good evidence for the use of non-sedating antihistamines in the common cold.
That said, in overdose selectivity is lost and patients can develop increased sedation, anticholinergic effects and hypotension.
QT prolongation occurs secondary to potassium channel blockade.
Histamine, acting on H-antihistamines help against these effects, they work only if taken before contact with the allergen.
In severe allergies, such as anaphylaxis or angioedema, these effects may be of life-threatening severity.
Additional administration of epinephrine, often in the form of an autoinjector (Epi-pen), is required by people with such hypersensitivities.